6/29/2023 0 Comments Clon waLoss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma). Normal cells generally display a rather intense nuclear p21 expression. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. Recombinant human p21 protein was used as immunogen to generate the antibody. Western Blot, Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry 0.5-1ug/ml, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
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